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New data on impact of spike mutations and B117 UK variant on neutralization by mAbs and sera – News-Medical.Net

A recent paper by British and Dutch scientists, currently available on the bioRxiv* preprint server, shows that the neutralizing activity of monoclonal antibodies…

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A recent paper by British and Dutch scientists, currently available on the bioRxiv* preprint server, shows that the neutralizing activity of monoclonal antibodies can be dramatically reduced by mutations of the SARS-CoV-2 spike glycoprotein – unlike polyclonal antibodies generated after natural infection that remain active regardless of any introduced amino acid changes.
Serum neutralization activity is considered the most important correlate of protection against viral infections after natural…

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