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Wistar Researchers Develop New Humanized Mouse Model That Provides Insight Into Immunotherapy Resistance – Newswise

Wistar scientists have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in

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Newswise — PHILADELPHIA — (Jan. 12, 2021) — Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published today in the journal Nature Communications.
Checkpoint inhibitors revolutionized therapeutic options for advanced melanoma. However, only a fraction of patients respond to this treatment and…

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