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High-affinity SARS-CoV-2 RBD drives mutation spread, forms basis of new COVID-19 inhibitor – News-Medical.Net

Now, an intriguing recent study appeared on the bioRxiv * preprint server describes the use of in vitro evolution to elicit affinity maturation of the viral receptor-binding…

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The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to spread, with the virus responsible for it, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoing many mutations that have affected its infectivity. Now, an intriguing recent study appeared on the bioRxiv * preprint server describes the use of in vitro evolution to elicit affinity maturation of the viral receptor-binding domain (RBD) of the spike protein to bind the host cell angiotensin-converting enzyme…

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