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Are SARS-CoV-2 protease inhibitors effective antivirals in treating COVID-19? – News-Medical.Net

Many antiviral development studies have focused on the possibility of inhibiting the main viral protease (Mpro), and papain-like protease (PLpro), given their central…

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In the search for effective antivirals to prevent and treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, scientists have investigated the possibility of inhibiting the main viral protease (Mpro), and papain-like protease (PLpro), that are key to its replication. Many compounds that inhibit these enzymes have been described and are advancing through the drug development pathway.
However, a new study, released on the bioRxiv* server in November 2020, draws attention to the…

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