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Coronavirus in human diseases: Mechanisms and advances in clinical treatment – Wiley

Current mechanisms of anti‐CoV therapeutic strategies. The idea to disturb the normal life cycle of the virus provides significant insights into the clinical tr…



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4.2.1 Agents based on viral enzymes
All of the major proteases of the virus are attractive druggable targets since they are essential for viral transcription and replication (Table 2). As a key part of replicationtranscription complex, RdRp participates in the production of genomic RNA and subgenomic RNA. Nucleoside analogues targeting RdRp is capable of inhibiting viral RNA synthesis in a great variety of RNA viruses including CoVs.246-250 Favipiravir (T705), a guanine analogue approved in Jap…

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