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Genome of Fleming’s Original Penicillium Strain Could Point to New Routes for Industrial Manufacture – Genetic Engineering & Biotechnology News

Scientists revived a sample of Fleming’s Penicillium mold that had been frozen alive more than 50 years ago, and sequenced its genome for comparison with that of modern industrial strains.

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Researchers from Imperial College London, CABI, and the University of Oxford, have sequenced the genome of Alexander Fleming’s penicillin mold for the first time, and compared it to strains that are used for industrial penicillin manufacture today. The results indicate that the Fleming strain and the U.S. strain use slightly different mechanisms to produce penicillin, which could point to new routes for industrial production.
Research lead Timothy Barraclough, PhD, from the Department of Life S…

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