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Faulty transportation of messenger RNA is the culprit in ALS – EurekAlert

A team including Osaka University researchers has discovered a function for the protein missing in many types of ALS and FTLD, two neurodegenerative diseases. In neurons, the protein TDP-43 bound to messenger RNA that codes for pieces of ribosomes, the struct…



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IMAGE: Model of ALS/FTLD pathology associated with abnormal deposition of TDP-43
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Credit: National Center of Neurology and Psychiatry
Osaka, Japan — As the current COVID-19 crisis has shown, the disruptions that occur when transportation cannot proceed as usual are system-wide, affecting individual lives, companies, and the global economy. Now imagine a similar problem inside your brain and spinal cord. A new study led by researchers from Osaka University and National Center of Ne…

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