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PARP enzymes can bring two broken DNA ends together, shows study – News-Medical.net

Scientists at St. Jude Children’s Research Hospital have identified the structure of double-strand DNA break repair by PARP enzymes. The findings show that PARP…

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Reviewed by Emily Henderson, B.Sc.Sep 16 2020
Scientists at St. Jude Children’s Research Hospital have identified the structure of double-strand DNA break repair by PARP enzymes. The findings show that PARP2 can bridge the gap, bringing two broken DNA ends together.
The study also provides insight into the mechanisms that underlie PARP activation and the catalytic cycle, which may aid in understanding resistance to cancer drugs that inhibit PARP. The work appears as an advance online publicati…

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