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Antiviral effects of honeysuckle decoction affected in SIDT1poly population – News-Medical.net

Previously, Chen-Yu Zhang’s group have identified SID1 transmembrane family member 1 (SIDT1) as a critical membrane protein mediating dietary miRNAs absorption,…

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Reviewed by Emily Henderson, B.Sc.Sep 11 2020
Previously, Chen-Yu Zhang’s group have identified SID1 transmembrane family member 1 (SIDT1) as a critical membrane protein mediating dietary miRNAs absorption, which is abolished in SIDT1 deficient mice. In the present study, they demonstrate a significant frequency of human population (16%) that carry a SIDT1 polymorphism with amino acid replacement (Val78Met).
Functional analysis reveals that such polymorphism (SIDT1poly) undermines its low pH-d…

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